Immunoloogia põhialustega tutvumine ja nende omandamine. Arusaamine immuunsüsteemi komponentidest ning immuunsüsteemi arengu molekulaarsetest ja rakulistest protsessidest. Teha selgeks immuunsüsteemi funktsioneerimine normaalses tasakaalu olekus versus haigusete kontekstis ning immuunoteraapiate ja vaktsiinide kasutamine. Omandatakse oskus teadmiste rakendamiseks praktilises (uurimis)töös.

The student achieves the aims by acquiring knowledge of the immune system, its subcomponents and molecular and cellular processes for development of the immune system, how the immune system functions in healthy people and in immunological disease, cancer and transplantation and how immunotherapies and vaccinations can be used to hamper or prevent disease. This knowledge is acquired through lectures that cover the whole field of immunology through self-studies and through laboratory sessions, where students learn important and common immunological methods.

Üliõpilane on omandanud immunoloogia põhialused, saab neist aru, oskab kirjeldada organismi immuunsüsteemi vastuseid erinevate antigeenide puhul ning oskab kasutada mitmeid immuunoanalüüsi meetodeid eksperimentaaltöös.
Peale kursuse edukat läbimist on tudengid võimelised:
- kasutama immunoloogilist terminoloogiat
- tundma immuunrakkude funktsioone ja levikut organismis
- kirjeldama immuunvastust erinevatele infektsioonidele
-aru saama immuunoteraapiast ja vaktsiinide kasutamisest
-valdama erinevaid immunoloogilisi meetodeid, analüüsima andmeid, tegema järeldusi ja genereerime hüpoteese.

To give a broad and detailed overview of the field of immunology and detailed knowledge about many of the most important immunological technologies. Students have acquired the basics of immunology, are able to describe the response of the immune system to various antigens, can apply several methods of immunoanalysis in experiments.

After the course, students will be able to:
- use immunological terminology
- account for the different haematopoietic cell groups regarding phenotype, function and distribution
- account for the immune response against different pathogens and how these pathogens through different virulence factors influence the immune system possibilities to combat the infection
- account for various types of immunotherapies and vaccinations
- account for different immunological methods and be able to apply a number of these
- analyse data from immunological trials, draw conclusions and generate hypotheses

1. Ülevaade immunsüsteemist. (Kaasasündinud ja omandatud immuunsus).
2. Immuunsüsteemiga seotud organid ja rakud.
3. Retseptorid ja signaali ülekandmine (BCR,
 Antikehade struktuur. TCR, retseptorite paljuseuse genereerimine).
4. Tsütokiinid ja kemokiinid
5. Innate immuunsus (Barjäärid, komplement, fagotsütoos, NK, põletikuline vastus)
Esimene eksam (25%)
6.Lümfotsüütide geenide organisatsioon ja ekspressioon
7. Põhiline koesobivus kompleks ja antigeenide esitlemine.
8. T raku areng, aktiveerumine differentseerumine
9. B raku areng, aktiveerumine differentseerumine.
10. Allergia, ülitundlikkus ja kroonilised põletikud
11. Tolerants, autoimmuunsus ja transplantatsioon
12. Viraalsed ja bakteriaalsed infektsioonid ja vaktsiinid
13. Fungaalsed ja parasiitsed infektsioonid ja vaktsiinid
14. Immuunpuudulikkus.
15. Kasvajad ja immuunsus
16. Eksperimentaalsed süsteemid ja immunoloogilised meetodid
Teine eksam (75%)
Instruktsioonid: õppeaine antakse loengute vormis, projekti tööna, teoreetiliste ja praktiliste ülesannetena ning seminari vormis. Osalemine projekti töös, teoreetiliste ja praktiliste ülesannete lahendamisel ning seminarides on kohustuslik.

1. Overview of the immune system (innate and adaptive immunity).
2. Cells, organs and microenvironment of the immune system (prim and sec imm organs).
3. Receptors and signalling (BCR, Ab structure, TCR, rearrangement, signal transduction).
4. Cytokines and chemikines
5. Innate immunity (barriers, Complement, Phagocytosis, NK, inflammatory response)
Preliminary examination (immunological terminology)- 25%
6. Organization and expression of lymphoid receptor genes
7. Major Histocompatibility Complex (MHC) and antigen presentation.
8. T cell development, activation and differentiation
9. B cell development, activation and differentiation
10. Allergy hypersensitivities and chronic inflammation
11. Tolerance, autoimmunity and transplantation
12. Infectious disease: Viral and bacterial infections and vaccines
13. Infectious disease: fungal and parasitic infections and vaccines
14. Immunodeficiency disorders
15. Cancer and immune system
16. Experimental systems and immunological methods
Exam

Eristav hindamine. Kaks eksamit, millele pääsemise eelduseks on Immunoloogia I praktilise kursuse läbimine ja laboratoorse töö protokolli esitamine. 


Differentiated assessment.
Modules: Theory 4 credits; Laboratory session 1 credits; Exercise 1 credits.
The theory module will be examined through two written tests, 1) theoretical knowledge, and 2) theoretical knowledge and theoretical laboratory skills and analysis of data and immunological problems. For the module laboratory sessions, accomplished laboratory sessions including laboratory reports, are required. The module Exercise requires implemented theoretical practical assignments that are presented orally, and active participation in project work that is presented in written form and orally.

Õpiku lugemine, filmide vaatamine, tutvumine soovitatud teadusajakirjades ilmunud artiklitega k.a. ülevaate artiklid.

Reading of recommended scientific articles and reviews.

1. Owen, J., Punt, J., Strandord, S., and Jones, P. (2013). Kuby Immunology seventh edition. (USA: W. H. Freemand and Company).

2. Abbas, Abul K; Lichtman, Andrew H; Pillai, Shiv (2012) Cellular and molecular immunology , 7. ed.

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